Pseudohypoxia: Difference between revisions
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'''Pseudohypoxia''' refers to increased [[cytosol]]ic ratio of free [[NADH]] to [[Nicotinamide adenine dinucleotide|NAD]] in cells.<ref>[http://diabetes.diabetesjournals.org/content/42/6/801] Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993</ref> |
'''Pseudohypoxia''' refers to increased [[cytosol]]ic ratio of free [[NADH]] to [[Nicotinamide adenine dinucleotide|NAD]] in cells.<ref>[http://diabetes.diabetesjournals.org/content/42/6/801] Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993</ref> |
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Research has shown that declining levels of NAD+ during aging cause pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the aging process.<ref>[http://www.cell.com/abstract/S0092-8674%2813%2901521-3] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013</ref> It is expected that human NAD trials will begin in 2014.<ref>[ |
Research has shown that declining levels of NAD+ during aging cause pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the aging process.<ref>[http://www.cell.com/abstract/S0092-8674%2813%2901521-3] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013</ref> It is expected that human NAD trials will begin in 2014.<ref>[https://www.theguardian.com/science/2013/dec/20/anti-ageing-human-trials?CMP=EMCNEWEML6619I2] Guardian Newspaper - Online, Dec 2013</ref> |
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== See also == |
== See also == |
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Revision as of 04:33, 16 December 2016
Pseudohypoxia refers to increased cytosolic ratio of free NADH to NAD in cells.[1] Research has shown that declining levels of NAD+ during aging cause pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the aging process.[2] It is expected that human NAD trials will begin in 2014.[3]
See also
- Hypoxia (medical)
- Hypoxia (disambiguation) - list under Hypoxia (medical) e.g Intrauterine hypoxia
References
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