Nicotinate phosphoribosyltransferase: Difference between revisions
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Thus, the four [[substrate (biochemistry)|substrates]] of this enzyme are [[nicotinate]], [[Phosphoribosyl pyrophosphate|5-phospho-alpha-D-ribose 1-diphosphate]], [[Adenosine triphosphate|ATP]], and [[Water|H<sub>2</sub>O]], whereas its four [[product (chemistry)|products]] are [[nicotinate D-ribonucleotide]], [[diphosphate]], [[Adenosine diphosphate|ADP]], and [[phosphate]]. |
Thus, the four [[substrate (biochemistry)|substrates]] of this enzyme are [[nicotinate]], [[Phosphoribosyl pyrophosphate|5-phospho-alpha-D-ribose 1-diphosphate]], [[Adenosine triphosphate|ATP]], and [[Water|H<sub>2</sub>O]], whereas its four [[product (chemistry)|products]] are [[nicotinate D-ribonucleotide]], [[diphosphate]], [[Adenosine diphosphate|ADP]], and [[phosphate]]. |
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This enzyme belongs to the family of [[ligase]]s, specifically those forming generic carbon-nitrogen bonds. The [[List of enzymes|systematic name]] of this enzyme class is '''5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) '''. Other names in common use include '''niacin ribonucleotidase''', '''nicotinic acid mononucleotide glycohydrolase''', '''nicotinic acid mononucleotide pyrophosphorylase''', and '''nicotinic acid phosphoribosyltransferase'''. This enzyme participates in [[nicotinate and nicotinamide metabolism]]. |
This enzyme belongs to the family of [[ligase]]s, specifically those forming generic carbon-nitrogen bonds. The [[List of enzymes|systematic name]] of this enzyme class is '''5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) '''. Other names in common use include '''niacin ribonucleotidase''', '''nicotinic acid mononucleotide glycohydrolase''', '''nicotinic acid mononucleotide pyrophosphorylase''', and '''nicotinic acid phosphoribosyltransferase'''. This enzyme participates in [[nicotinate and nicotinamide metabolism]]. |
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==Structural studies== |
==Structural studies== |
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{{Ligases CO CS and CN}} |
{{Ligases CO CS and CN}} |
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{{Enzymes}} |
{{Enzymes}} |
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{{Portal bar|Biology|border=no}} |
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[[Category:EC 6.3.4]] |
[[Category:EC 6.3.4]] |
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[[Category:Enzymes of known structure]] |
[[Category:Enzymes of known structure]] |
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Revision as of 18:22, 24 September 2019
| nicotinate phosphoribosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Nicotinate phosphoribosyltransferase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 6.3.4.21 | ||||||||
| CAS no. | 9030-26-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a nicotinate phosphoribosyltransferase (EC 6.3.4.21) is an enzyme that catalyzes the chemical reaction
- nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
Thus, the four substrates of this enzyme are nicotinate, 5-phospho-alpha-D-ribose 1-diphosphate, ATP, and H2O, whereas its four products are nicotinate D-ribonucleotide, diphosphate, ADP, and phosphate.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) . Other names in common use include niacin ribonucleotidase, nicotinic acid mononucleotide glycohydrolase, nicotinic acid mononucleotide pyrophosphorylase, and nicotinic acid phosphoribosyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1VLP, 1YBE, 1YIR, 1YTD, 1YTE, 1YTK, and 2F7F.
References
- IMSANDE J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli". J. Biol. Chem. 236: 1494–7. PMID 13717628.
- IMSANDE J, HANDLER P (1961). "Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase". J. Biol. Chem. 236: 525–30. PMID 13717627.
- Kosaka A, Spivey HO, Gholson RK (1971). "Nicotinate phosphoribosyltransferase of yeast. Purification and properties". J. Biol. Chem. 246 (10): 3277–83. PMID 4324895.
