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Lotilaner: Difference between revisions

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more ids
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| DrugBank =
| DrugBank =
| UNII = HEH4938D7K
| UNII = HEH4938D7K
| ChemSpiderID = 32699771
| ChEMBL = 3707310
| KEGG = D11212
<!-- Chemical and physical data -->
<!-- Chemical and physical data -->
| C=20 | H=14 | Cl=3 | F=6 | N=3 | O=3 | S=1
| C=20 | H=14 | Cl=3 | F=6 | N=3 | O=3 | S=1

Revision as of 00:30, 2 December 2019

Lotilaner
Clinical data
Trade namesCredelio
Identifiers
  • 3-Methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H14Cl3F6N3O3S
Molar mass596.75 g·mol−1
3D model (JSmol)
  • CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

Lotilaner (INN; trade name Credelio) is a veterinary drug used to control fleas and ticks in dogs.[1] It is indicated for for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations including lone star tick (Amblyomma americanum), American dog tick (Dermacentor variabilis), black-legged tick (Ixodes scapularis), and brown dog tick (Rhipicephalus sanguineus).[2]

References

  1. ^ Kuntz, Emmanuelle A.; Kammanadiminti, Srinivas (2017). "Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™)". Parasites & Vectors. 10. doi:10.1186/s13071-017-2468-y.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  2. ^ "FREEDOM OF INFORMATION SUMMARY, SUPPLEMENTAL NEW ANIMAL DRUG APPLICATION, NADA 141-494, Credelio, Lotilaner, Chewable Tablets, Dogs". September 3, 2019.