Eleanor Barnes
Eleanor (Ellie) Barnes | |
|---|---|
| Alma mater | University of Oxford St Bartholomew's Hospital |
| Scientific career | |
| Institutions | John Radcliffe Hospital University of Oxford |
| Thesis | T-cell and dendritic cell function and the effects of combination therapy in Hepatitis C virus infection (2004) |
Eleanor (Ellie) Barnes is a British physician at the John Radcliffe Hospital and a Professor of Hepatology and Experimental Medicine at the University of Oxford. She has studied Hepatitis C and the development of the development of HCV vaccines. She led international research efforts investigating IgG4 disease. She is a Fellow of the Academy of Medical Sciences.
Early life and education
Barnes has said that she was interested in science as a child.[1] She decided to study medicine at university, and eventually trained in medicine at St Bartholomew's Hospital.[1] She completed an intercalated bachelor's degree in anthropology and philosopy.[1] After graduating she worked as a medical resident at the Royal Free Hospital, where she decided to specialise in hepatology and gastroenterology. Determined to pursue a career in research, Barnes worked unpaid for several months, during which time she obtained data that she used to apply for a fellowship from the Medical Research Council. She was a doctoral researcher at the University of Oxford. Her doctoral research considered T cell and dendritic cell function.[2]
Research and career
Her research considers T cell immunology. She is focussed on the translation of laboratory findings to clinical environments. Barnes worked as a Medical Research Council Senior Fellow at the University of Oxford, and eventually was appointed lead of herpetology in the Thames Valley.[3][4] She studied why 80% of patients with Hepatitis C get chronic infection.[3] Barnes identified that the nature of the T cell response determines which pathway a patient goes down. This observation led Barnes to develop an T-cell vaccine to prevent Hepatitis C infection. The vaccine is based on adenoviral vectors, which host the non-structural proteins of Hepatitis C from a genotype 1B strain.[3] There are seven major Hepatitis C strains, which presents considerable challenges for the development of vaccines.[3] Barnes was elected Fellow of the Academy of Medical Sciences in 2018.[5]
During the COVID-19 pandemic Barnes studied the design, effectiveness and implementation of the COVID-19 vaccine.[6] She showed that patients who suffered from COVID-19 were likely to be impacted by liver problems.[7]
Select publications
- Jane P Messina; Isla Humphreys; Abraham Flaxman; Anthony Brown; Graham S Cooke; Oliver G Pybus; Eleanor Barnes (28 July 2014). "Global distribution and prevalence of hepatitis C virus genotypes". Hepatology. 61 (1): 77–87. doi:10.1002/HEP.27259. ISSN 0270-9139. PMC 4303918. PMID 25069599. Wikidata Q34431175.
- Merryn Voysey; Sue Ann Costa Clemens; Shabir A Madhi; et al. (8 December 2020). "Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK". The Lancet. 397 (10269): 99–111. doi:10.1016/S0140-6736(20)32661-1. ISSN 0140-6736. PMC 7723445. PMID 33306989. Wikidata Q104286457.
- Pedro M Folegatti; Katie J Ewer; Parvinder K Aley; et al. (20 July 2020). "Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial". The Lancet. doi:10.1016/S0140-6736(20)31604-4. ISSN 0140-6736. PMC 7445431. PMID 32702298. Wikidata Q97678476.
Personal life
Barnes is married with two children.[3]
References
- ^ a b c "Eleanor Barnes — Diversity Projects". parking.haiku.fry-it.com. Retrieved 2021-09-18.
- ^ Barnes, Eleanor (2004). T-cell and dendritic cell function and the effects of combination therapy in Hepatitis C virus infection (Thesis).
- ^ a b c d e "Ellie Barnes: Women in Science - Internal Speaker — Working for NDM". www.ndm.ox.ac.uk. Retrieved 2021-09-18.
- ^ "PITCH Study". www.pitch-study.org. Retrieved 2021-09-18.
- ^ "Professor Eleanor Barnes | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2021-09-18.
- ^ "UK scientists back Covid boosters as study finds post-jab falls in antibodies". the Guardian. 2021-07-22. Retrieved 2021-09-18.
- ^ "Liver problems common among COVID-19 patients, study finds". NIHR Oxford Biomedical Research Centre. 2021-07-23. Retrieved 2021-09-18.