Exercise mimetic
An exercise mimetic is a drug that mimics some of the biological effects of physical exercise, via activating some pathways that are believed to be affected by exercise. Targets of exercise mimetics include irisin, brain-derived neurotrophic factor, interleukin-6, AMP-activated protein kinase (e.g. 5-aminoimidazole-4-carboxamide ribonucleotide), peroxisome proliferator-activated receptor delta (e.g. GW501516), and estrogen-related receptor γ (e.g. GSK4716).[2]
The majority of the effect of exercise in reducing cardiovascular and all-cause mortality cannot be explained via improvements in quantifiable risk factors, such as blood cholesterol. This further increases the challenge of developing an effective exercise mimetic.[1] Moreover, even if a broad spectrum exercise mimetic were invented, it is not necessarily the case that its public health effects would be superior to interventions to increase exercise in the population.[1]
References
- ^ a b c Hawley, John A.; Joyner, Michael J.; Green, Daniel J. (February 2021). "Mimicking exercise: what matters most and where to next?". The Journal of Physiology. 599 (3): 791–802. doi:10.1113/JP278761. ISSN 0022-3751.
- ^ Jang, Young Jin; Byun, Sanguine (31 December 2021). "Molecular targets of exercise mimetics and their natural activators". BMB Reports. 54 (12): 581–591. doi:10.5483/BMBRep.2021.54.12.151. ISSN 1976-6696.