G protein-coupled bile acid receptor

G protein-coupled bile acid receptor 1
G protein-coupled bile acid receptor 1
Identifiers
Symbol	GPBAR1
Alt. symbols	BG37, GPCR, TGR5, M-BAR, GPCR19, GPR131, MGC40597
NCBI gene	151306
HGNC	19680
OMIM	610147
RefSeq	NM_001077191
UniProt	Q8TDU6
Other data
Locus	Chr. 2 q35
Structures
Search for
Structures	Swiss-model
Domains	InterPro

The G protein-coupled bile acid receptor is a G-protein coupled receptor which binds bile acids.^[1] One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T₄) to the active hormone triiodothyronine (T₃). T₃ in turn activates the thyroid hormone receptor which increases metabolic rate.^[2]^[3]

References

^ Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M (2003). "A G protein-coupled receptor responsive to bile acids". J. Biol. Chem. 278 (11): 9435–40. doi:10.1074/jbc.M209706200. PMID 12524422.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^ Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J (2006). "Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation". Nature. 439 (7075): 484–9. doi:10.1038/nature04330. PMID 16400329.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Baxter JD, Webb P (2006). "Metabolism: bile acids heat things up". Nature. 439 (7075): 402–3. doi:10.1038/439402a. PMID 16437098.

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