Pseudohypoxia

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Pseudohypoxia refers to increased cytosolic ratio of free NADH to NAD in cells^[1] Research has shown that declining NAD+ during aging causes pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the ageing process^[2]. It is expected that human NAD trials will begin in 2014 ^[3]

References

^ [1] Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993
^ [2] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013
^ [3]Guardian Newspaper - Online, Dec 2013

[1] [1] Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993

[2] [2] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013

[3] [3]Guardian Newspaper - Online, Dec 2013

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