Parathyroid hormone 2 receptor
PTH2R | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | PTH2R, PTHR2, parathyroid hormone 2 receptor | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601469; MGI: 2180917; HomoloGene: 3701; GeneCards: PTH2R; OMA:PTH2R - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene.[5]
Function
The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.[5]
The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding.[6]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000144407 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025946 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: PTH2R parathyroid hormone 2 receptor".
- ^ Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D (2017). "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5". Biochemical Pharmacology. doi:10.1016/j.bcp.2016.12.013.
Further reading
External links
- "Parathyroid Hormone Receptors: PTH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Receptor,+Parathyroid+Hormone,+Type+2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.