Jump to content

Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Allobarbital: Difference between pages

(Difference between pages)
Page 1
Page 2
Content deleted Content added
VisualWikitext
Saving copy of the {{drugbox}} taken from revid 476073778 of page Allobarbital for the Chem/Drugbox validation project (updated: '').
 
Class
 
Line 1: Line 1:
{{Short description|Chemical compound}}
{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid [{{fullurl:Allobarbital|oldid=476073778}} 476073778] of page [[Allobarbital]] with values updated to verified values.}}
{{Drugbox
{{Drugbox
| verifiedrevid = 413310317
| verifiedrevid = 477317940
| IUPAC_name = 5,5-diprop-2-enyl-1,3-diazinane-2,4,6-trione
| IUPAC_name = 5,5-di(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
| image = Allobarbital.svg
| image = Allobarbital.svg
| width = 120
| width = 120
| image2 = Allobarbital ball-and-stick animation.gif

| width2 = 160
<!--Clinical data-->
<!--Clinical data-->
| tradename =
| tradename =
Line 12: Line 13:
| pregnancy_category =
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_BR = B1
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-03-31 |title=RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |url-status=live |archive-url=https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |archive-date=2023-08-03 |access-date=2023-08-16 |publisher=[[Diário Oficial da União]] |language=pt-BR |publication-date=2023-04-04}}</ref>
| legal_CA = Schedule IV
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_US = Schedule III
| legal_DE = Anlage III
| legal_status =
| legal_status =
| routes_of_administration =
| routes_of_administration =
| class = [[Barbiturate]]

<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
| bioavailability =
| bioavailability =
Line 24: Line 28:
| elimination_half-life =
| elimination_half-life =
| excretion =
| excretion =

<!--Identifiers-->
<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 52-43-7
| CAS_number = 52-43-7
| ATC_prefix = N05
| ATC_prefix = N05
Line 41: Line 44:
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 267719
| ChEMBL = 267719

<!--Chemical data-->
<!--Chemical data-->
| C=10 | H=12 | N=2 | O=3
| C=10 | H=12
| N=2 | O=3
| molecular_weight = 208.214 g/mol
| smiles = O=C1NC(=O)NC(=O)C1(C\C=C)C\C=C
| smiles = O=C1NC(=O)NC(=O)C1(C\C=C)C\C=C
| InChI = 1/C10H12N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-4H,1-2,5-6H2,(H2,11,12,13,14,15)
| InChIKey = FDQGNLOWMMVRQL-UHFFFAOYAS
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H12N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-4H,1-2,5-6H2,(H2,11,12,13,14,15)
| StdInChI = 1S/C10H12N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-4H,1-2,5-6H2,(H2,11,12,13,14,15)
Line 54: Line 54:
| synonyms = 5,5-Diallylbarbituric acid, Allobarbital
| synonyms = 5,5-Diallylbarbituric acid, Allobarbital
}}
}}
'''Allobarbital''', also known as '''allobarbitone''' and branded as '''Dial''', '''Cibalgine''' (in combination with [[aminophenazone]]), or '''Dial-Ciba''' (in combination with [[ethyl carbamate]]), is a [[barbiturate]] derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for [[Ciba Specialty Chemicals|CIBA]]. It was used primarily as an [[anticonvulsant]]<ref>{{cite journal | vauthors = Chocholová L, Radil-Weiss T | title = Effect of allobarbital on focal epilepsy in rats | journal = Physiologia Bohemoslovaca | volume = 20 | issue = 4 | pages = 325–34 | year = 1971 | pmid = 4335127 }}</ref> although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of [[analgesic]] drugs, and use in the treatment of [[insomnia]] and [[anxiety]].

Allobarbital was never particularly widely used compared to better known barbiturates such as [[phenobarbital]] and [[secobarbital]], although it saw more use in some European countries such as [[Bulgaria]] and [[Slovakia]],<ref>{{cite journal | vauthors = Getova D, Georgiev V | title = GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists | journal = Acta Physiologica et Pharmacologica Bulgarica | volume = 13 | issue = 3 | pages = 43–50 | year = 1987 | pmid = 3439474 }}</ref> and is still used in for example Poland, but only as compound.<ref>{{cite web|title=APTECZKA BABUNI - KROPLE ŻOŁĄDKOWE KROPLE 20 G |trans-title=GRANDMA'S FIRST AID KIT - DROPS - STOMACH DROPS 20 G |website=Domzdrowia.pl |language=Polish |url=http://www.domzdrowia.pl/29439,apteczka-babuni-krople-zoladkowe-krople-20-g.html |archive-url=https://web.archive.org/web/20071031195035/http://www.domzdrowia.pl/29439%2Capteczka-babuni-krople-zoladkowe-krople-20-g.html |archive-date=October 31, 2007 |access-date=March 10, 2013 |url-status=live }}</ref>

== References ==
{{reflist}}

{{Hypnotics and sedatives}}
{{GABAAR PAMs}}

[[Category:Barbiturates]]
[[Category:Allyl compounds]]
Retrieved from "https://en.wikipedia.org/wiki/Special:ComparePages"