Didesmethylcitalopram: Difference between revisions
Appearance
Content deleted Content added
Updating {{drugbox}} (changes to watched fields - added verified revid - updated 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [ |
Importing Wikidata short description: "Chemical compound" (Shortdesc helper) |
||
(16 intermediate revisions by 14 users not shown) | |||
Line 1: | Line 1: | ||
{{Short description|Chemical compound}} |
|||
{{Drugbox |
{{Drugbox |
||
| Verifiedfields = changed |
|||
| Watchedfields = changed |
| Watchedfields = changed |
||
| verifiedrevid = |
| verifiedrevid = 451228130 |
||
| IUPAC_name = (''RS'' or ''S'')-1-[3-aminopropyl]-1-<br/>(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile |
| IUPAC_name = (''RS'' or ''S'')-1-[3-aminopropyl]-1-<br/>(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile |
||
| image = Didesmethylescitalopram skeletal.svg |
| image = Didesmethylescitalopram skeletal.svg |
||
| width |
| width = |
||
⚫ | |||
| imagename = Didesmethylescitalopram |
|||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
| CAS_number_Ref = {{cascite|correct|CAS}} |
|||
⚫ | |||
⚫ | |||
⚫ | |||
| UNII_Ref = {{fdacite|correct|FDA}} |
|||
| UNII = ZE9YVI4ZEE |
|||
⚫ | |||
⚫ | |||
⚫ | |||
| ATC_suffix = |
|||
⚫ | |||
| |
| PubChem = |
||
⚫ | |||
| PubChem = |
|||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
| smiles = c1cc(ccc1[C@]2(c3ccc(cc3CO2)C#N)CCCN)F |
|||
⚫ | |||
| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
|||
| StdInChI = 1S/C18H17FN2O/c19-16-5-3-15(4-6-16)18(8-1-9-20)17-7-2-13(11-21)10-14(17)12-22-18/h2-7,10H,1,8-9,12,20H2/t18-/m0/s1 |
|||
⚫ | |||
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
|||
⚫ | |||
| StdInChIKey = RKUKMUWCRLRPEJ-SFHVURJKSA-N |
|||
| molecular_weight = 296.338783 g/mol |
|||
⚫ | |||
⚫ | |||
}} |
}} |
||
⚫ | '''Didesmethylcitalopram''' is an [[active metabolite]] of the [[antidepressant]] [[drug]] [[citalopram]] ([[racemic]]).<ref name="pmid2365786">{{cite journal | vauthors = Rop PP, Durand A, Viala A, Jørgensen A | title = Simultaneous determination of citalopram, monodesmethylcitalopram and didesmethylcitalopram in plasma by high-performance liquid chromatography after column extraction | journal = Journal of Chromatography | volume = 527 | issue = 1 | pages = 226–32 | date = April 1990 | pmid = 2365786 | doi = 10.1016/s0378-4347(00)82105-2 }}</ref> '''Didesmethyl''es''citalopram''' is an active metabolite of the antidepressant [[escitalopram]], the ''S''-[[enantiomer]] of citalopram. Like citalopram and escitalopram, didesmethyl(es)citalopram functions as a [[selective serotonin reuptake inhibitor]] (SSRI), and is responsible for some of its parents' [[therapeutic benefit]]s. |
||
⚫ | '''Didesmethylcitalopram''' is an [[ |
||
== See also == |
== See also == |
||
{{div col|colwidth=30em}} |
|||
<div style="-moz-column-count:2; column-count:2; -webkit-column-count:2;"> |
|||
* [[Desmethylcitalopram]] |
* [[Desmethylcitalopram]] |
||
* [[Desmethylsertraline]] |
* [[Desmethylsertraline]] |
||
* [[Desmethylvenlafaxine]] |
* [[Desmethylvenlafaxine]] |
||
* [[Norfluoxetine]] |
* [[Norfluoxetine]] |
||
{{div col end}} |
|||
</div> |
|||
== References == |
== References == |
||
{{Reflist |
{{Reflist}} |
||
{{Antidepressants}} |
{{Antidepressants}} |
||
{{Serotonergics}} |
{{Serotonergics}} |
||
⚫ | |||
⚫ | |||
⚫ | |||
[[Category:Human drug metabolites]] |
|||
{{nervous-system-drug-stub}} |
{{nervous-system-drug-stub}} |
||
⚫ | |||
⚫ | |||
⚫ |