Oxametacin

Oxametacin
Clinical data
ATC code	M01AB13 (WHO) ;
Identifiers
	IUPAC name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-hydroxyacetamide;
CAS Number	27035-30-9 ;
PubChem CID	33675;
ChemSpider	31057 ;
UNII	8G02RSW5CM;
KEGG	D07266 ;
ChEBI	CHEBI:76255 ;
ChEMBL	ChEMBL295829 ;
CompTox Dashboard (EPA)	DTXSID70181517 ;
ECHA InfoCard	100.043.785
Chemical and physical data
Formula	C19H17ClN2O4
Molar mass	372.81 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NO;
	InChI InChI=1S/C19H17ClN2O4/c1-11-15(10-18(23)21-25)16-9-14(26-2)7-8-17(16)22(11)19(24)12-3-5-13(20)6-4-12/h3-9,25H,10H2,1-2H3,(H,21,23) ; Key:AJRNYCDWNITGHF-UHFFFAOYSA-N ;
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Oxametacin (or oxamethacin) is a non-steroidal anti-inflammatory drug.^[1]

Hydrolysis of the amide group is one of the synthetic pathways to Deboxamet (ChemDrug).

References

^ Schweiger J (1999). "Oxametacin". In von Bruchhausen F, Ebel S, Hackenthal E, Holzgrabe U (eds.). Hagers Handbuch der Pharmazeutischen Praxis: Stoffe L-Z Folgeband 5 (in German) (5th, vollständig neubearbeitete Auflage ed.). Berlin, Heidelberg. pp. 367–368. ISBN 978-3-642-58388-9.{{cite book}}: CS1 maint: location missing publisher (link)

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[1] Schweiger J (1999). "Oxametacin". In von Bruchhausen F, Ebel S, Hackenthal E, Holzgrabe U (eds.). Hagers Handbuch der Pharmazeutischen Praxis: Stoffe L-Z Folgeband 5 (in German) (5th, vollständig neubearbeitete Auflage ed.). Berlin, Heidelberg. pp. 367–368. ISBN 978-3-642-58388-9.{{cite book}}: CS1 maint: location missing publisher (link)

[1]

v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine^† Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; ^#WHO-Essential Medicines; ^†withdrawn drugs; ^‡veterinary use.
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