User:Patelurology2/DrugIP
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DrugIP ...
Structural relationships of drugs
- :Pubmed"Structure-Activity Relationship"[MeSH Terms drug induced pancreatitis ]
- Pancreatitis SAR related citation
- Structure-activity relationships in drug-induced pancreatic islet cell toxicity.
- Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells: A Plausible Mechanism for Tissue Injury-Associated Pancreatitis
- Proteolysis
- Apoptosis
- Chymotrypsin
- Disulfide bond
- Valproic acid Valproic acid also blocks the voltage-gated sodium channels and T-type calcium channels.
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What links to Pancreatitis
see in edit mode Linezolid a weak monoamine oxidase inhibitor (MAOI)
Drug vs mechanism of pancreatitis
Drug Name: In Frequency of occurrence | References | No. of Reported Cases | No. of Cases Following Re-exposure | Age Range of Patients (yr) | Class & e.g. | Mechanism of the class: & individual drugs | Mechanism of pacreatitis | SAR-others in class: Mechanism Parsing | Basic Mechanisms Class X ref match 1 to... | Basic Mechanisms Class X ref match ... n |
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Didanosine | 13–17 | 883 | 9 | 2.5–61 | A. Anitmicrobials
1. Antivirals a. Nucleoside reverse transcriptase inhibitors Abacavir, Didanosine, Lamivudine, Stavudine, Zalcitabine, Zidovudine |
Inhibition of mitochondrial DNA polymerase-gamma leads to impaired oxidative phosphorylation and failure to synthesize ATP | ||||
Asparaginase | 18–22 | 177 | 2 | 2 –75 | D. Antineoplastic agents 2. Leukemia medications
e.g. Asparaginase, Pegasparaginase in acute lymphoblastic leukemia (ALL) |
cystic fibrosis transmembrane conductance regulator (CFTR) gene have been associated with pancreatitis in people without cystic fibrosis. | ||||
Drug Name: In Frequency of occurrence | References | No. of Reported Cases | No. of Cases Following Re-exposure | Age Range of Patients (yr) | Class & e.g. | Mechanism of the class: & individual drugs | Mechanism of pacreatitis | SAR-others in class: Mechanism Parsing | Basic Mechanisms Class X ref match 1 to... | Basic Mechanisms Class X ref match ... n |
Azathioprine | 23–27 | 86 | 16 | 11–65 | F. GI agents
3. IBD medications a. Aminosalicylates Balsalazide, Mesalamine, Olsalazine, Sulfasalazine b. Others Azathioprine, Mercaptopurine |
antagonist to purine metabolism, may inhibit RNA and DNA synthesis.
Thedrug may also be incorporated into nucleic acids resulting in chromosome breaks, malfunctioning of the nucleic acids, or synthesis of fraudulent proteins. the drug may also inhibit coenzyme formation and functioning, thereby interfering with cellular metabolism. Mitosis may be inhibited by the drug. |
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Valproic acid | 80 | 11 | 1–65 | C. Neuropsychiatric agents
1. Anticonvulsants Carbamazepine, Divalproex sodium, Felbamate, Gabapentin, Lamotrigine, Topiramate, Valproic acid |
Reduction of superoxide dismutase, catalase, and glutathione peroxidase, which are in charge of removing free radicals. The increase of free radicals can lead to an increase of endothelial permeability and lipid peroxidation | |||||
Pentavalent antimonials | 33–40 | 80 | 14 | 19–62 | Sodium stibogluconate and Ureastibamine | Specifically inhibit the relaxation of supercoiled plasmid pBR322 catalyzed by DNA topoisomerase I of Leishmania donovani. Dose dependent inhibition suggests that the drugs interact with the enzyme rather than the DNA | pancreatitis subsides when therapy is stopped, and rechallenge may be tolerated after a brief halt in treatment | |||
Drug Name: In Frequency of occurrence | References | No. of Reported Cases | No. of Cases Following Re-exposure | Age Range of Patients (yr) | Class & e.g. | Mechanism of the class: & individual drugs | Mechanism of pacreatitis | SAR-others in class: Mechanism Parsing | Basic Mechanisms Class X ref match 1 to... | Basic Mechanisms Class X ref match ... n |
Pentamidine | 41–45 | 79 | 2 | 14–63 | Glucose abnormalities, renal insufficiency, and non-specific abdominal pain may be early warning signs of pentamidine-associated pancreatitis. | |||||
Mercaptopurine | 46–50 | 69 | 10 | 6–40 | Treat leukemia, pediatric non-Hodgkin's lymphoma,[citation needed] polycythemia vera,[2] psoriatic arthritis,[3] and inflammatory bowel disease (such as Crohn's disease and ulcerative colitis | 6-MP ribonucleotide inhibits purine nucleotide synthesis and metabolism. This alters the synthesis and function of RNA and DNA. Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. Patients exhibiting myelosuppression or bone marrow toxicity should be tested for thiopurine methyltransferase (TPMT) enzyme deficiency. Patients with TPMT deficiency are much more likely to develop dangerous myelosuppression.[6] In such patients, it may be possible to continue using mercaptopurine, but at a lower dose | ||||
Mesalamine | 51–55 | 59 | 18–43 | Sulphasalazine is an active agent in the treatment of chronic inflammatory bowel disease Sulphasalazine is composed of sulphapyridine and mesalazine (5-aminosalicylic acid, 5-ASA or mesalazine) joined by an azo bond | 5-aminosalicylic acid (5-ASA) is the active moiety of sulphasalazine | |||||
Various estrogens56–60 42 11 21–53 Opiates61–65 42 5 8–74 Tetracycline60,66–68 34 2 10–72 Cytarabine69–72 26 4 14–73 Steroids73–77 25 1 2–88 Sulfamethoxazole/trimethoprim78–81 24 1 26–62 Sulfasalazine82–84 23 5 12–54 Furosemide85–88 21 3 23–74 Sulindac89–93 21 8 31–91 Class II Rifampin94 25 0 57 Lamivudine95 19 1 34–63 Octreotide96–99 16 4 24–66 Carbamazepine100–102 14 0 5–73 Acetaminophen103–106 13 1 19–74 Phenformin*,107–111 13 1 39–87 Interferon-afa 2b112–114 12 2 38–54 Enalapril115–119 12 2 23–69 Hydrochlorothiazide120 12 1 11–72 Cisplatin121 11 1 9–41 Erythromycin106,122–124 11 1 12–75 Cyclopenthiazide*,125 11 0 ? |
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Drug Name: In Frequency of occurrence | References | No. of Reported Cases | No. of Cases Following Re-exposure | Age Range of Patients (yr) | Class & e.g. | Mechanism of the class: & individual drugs | Mechanism of pacreatitis | SAR-others in class: Mechanism Parsing Predicting Protein Ligand Binding Sites by Combining Evolutionary Sequence Conservation and 3D Structure | Basic Mechanisms Class X ref match 1 to... | Basic Mechanisms Class X ref match ... n |
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- diabetes-drugs-may-cause-damage-to-pancreas
- Liraglutide (Victoza)-It has the potential for inhibiting apoptosis and stimulating regeneration of beta cells (seen in animal studies).
- Exenatide (Byetta)
- Albiglutide
- Taspoglutide
References
External links
- Drug-Induced Pancreatitis:An Update:Trivedi, Pitchumoni MD
- Byetta & Sitaglipin pancreatitis side effect
- Baylor Health article Drug-induced acute pancreatitis Tracie Kaurich, PharmD
- [1]
- Drug-Induced Pancreatitis:An Unlucky DIP:New Zealand Pharmacovigilance Centre
- Drug-induced acute pancreatitis ncbi
- Pancreatitis drug induced, mechanisms
- Pravastatin: A potential cause for acute pancreatitis
- Drug induced acute pancreatitis: incidence and severity. - follow the ncbi links for more review articles as below
- Reviw articles
- Drug-induced pancreatitis:an update:Trivedi CD, Pitchumoni CS
- Diabetes-drugs-may-cause-damage-to-pancreas