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Formate—dihydrofolate ligase

From Wikipedia, the free encyclopedia
Formate—dihydrofolate ligase
Identifiers
EC no.6.3.4.17
CAS no.123303-25-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a formate—dihydrofolate ligase (EC 6.3.4.17) is an enzyme that catalyzes the chemical reaction

ATP + formate + dihydrofolate ADP + phosphate + 10-formyldihydrofolate

The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming).

References

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Further reading

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  • Drake JC, Baram J, Allegra CJ (1990). "Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells" (PDF). Biochem. Pharmacol. 39 (3): 615–8. doi:10.1016/0006-2952(90)90073-T. PMID 2306274.