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Glutarate—CoA ligase

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Glutarate—CoA ligase
Identifiers
EC no.6.2.1.6
CAS no.9023-68-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a glutarate—CoA ligase (EC 6.2.1.6) is an enzyme that catalyzes the chemical reaction

ATP + glutarate + CoA ADP + phosphate + glutaryl-CoA

The 3 substrates of this enzyme are ATP, glutarate, and CoA, whereas its 3 products are ADP, phosphate, and glutaryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is glutarate:CoA ligase (ADP-forming). Other names in common use include glutaryl-CoA synthetase, and glutaryl coenzyme A synthetase. This enzyme participates in fatty acid metabolism and lysine degradation.

References

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  • Menon GK, Friedman DL, Stern JR (1960). "Enzymic synthesis of glutaryl-coenzyme A". Biochim. Biophys. Acta. 44: 375–377. doi:10.1016/0006-3002(60)91583-3. PMID 13769477.