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UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase

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UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
Identifiers
EC no.6.3.2.37
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UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase (EC 6.3.2.37, UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase, D-lysine-adding enzyme) is an enzyme with systematic name UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:D-lysine alpha-ligase (ADP-forming).[1] This enzyme catalyses the following chemical reaction

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysine ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-D-lysine

The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7.

References

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  1. ^ Boniface A, Bouhss A, Mengin-Lecreulx D, Blanot D (June 2006). "The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity". The Journal of Biological Chemistry. 281 (23): 15680–6. doi:10.1074/jbc.M506311200. PMID 16595662.
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