(Q909381)

Englisch

Interleukin 21

mammalian protein found in Homo sapiens

interleukin-21 isoform
IL21
interleukin-21
Za11

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No label defined

No description defined

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Statements

1 reference

13 November 2019

four-helical cytokine-like, core

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9HBE4

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IEA

interleukin-2 receptor binding

1 reference

8 April 2019

Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IPI

cell component

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HBE4&geneProductId=UniProtKB:Q9HBE4

3 references

8 April 2019

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IEA

biological process

positive regulation of inflammatory response

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IC

positive regulation of cytokine production

1 reference

8 April 2019

Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

1 reference

8 April 2019

IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IDA

positive regulation of B cell proliferation

1 reference

8 April 2019

Cloning and characterization of an isoform of interleukin-21

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IDA

positive regulation of tissue remodeling

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IEA

positive regulation of cell population proliferation

1 reference

8 April 2019

Cloning and characterization of an isoform of interleukin-21

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IDA

positive regulation of interleukin-17 production

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IDA

positive regulation of natural killer cell mediated cytotoxicity

1 reference

8 April 2019

Interleukin-21 activates human natural killer cells and modulates their surface receptor expression

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

1 reference

8 April 2019

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

NAS

tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IDA

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

Cloning and characterization of an isoform of interleukin-21

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IDA

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

IEA

interleukin-21-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

TAS

Gene Atlas image

PBB GE IL21 221271 at fs.png
732 × 530; 12 KB

0 references

Identifiers

MeSH descriptor ID

C416243

subject named as

interleukin-21

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

(Q909381)

Interleukin 21

Statements

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