A cyclized didemnimide alkaloid from the caribbean ascidian didemnumconchyliatum

HC Vervoort; W Fenical; PA Keifer

doi:10.1021/np980409q

A cyclized didemnimide alkaloid from the caribbean ascidian didemnumconchyliatum

J Nat Prod. 1999 Feb;62(2):389-91. doi: 10.1021/np980409q.

Authors

HC Vervoort¹, W Fenical, PA Keifer

Affiliation

¹ Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0236, and Varian NMR Instruments, 3120 Hansen Way, Palo Alto, California 94304, USA.

PMID: 10075798
DOI: 10.1021/np980409q

Abstract

A novel, cyclized alkaloid of the didemnimide class, 5, has been isolated from extracts of the Caribbean ascidian Didemnum conchyliatum. The structure of 5 was assigned using combined spectral methods that emphasized one- and two-dimensional NMR methods. The new alkaloid is the cyclization product of didemnimide A (1) formed via a C-2 indole condensation with the imidazole nitrogen.