An integrated model of sleep regulation

Stud Health Technol Inform. 1997:43 Pt B:581-5.

Abstract

We present a new model of sleep regulation which integrates the two process model and the limit cycle reciprocal interaction model. In the two process model the interaction of a homeostatic process (S signal) and of a circadian process determines the timing of sleep and waking. In the limit cycle model, the NREM-REM sleep cycle is generated by the reciprocal interaction of two coupled cell population. The present model integrates the two considered models introducing the trigger REM-NREM generated by the REM-ON signal and activated when REM-ON overcomes the S signal.

MeSH terms

  • Cerebral Cortex / physiopathology
  • Circadian Rhythm / physiology*
  • Computer Simulation*
  • Electroencephalography
  • Homeostasis / physiology
  • Humans
  • Narcolepsy / diagnosis
  • Narcolepsy / physiopathology
  • Polysomnography*
  • Reference Values
  • Signal Processing, Computer-Assisted
  • Sleep Stages / physiology*
  • Sleep, REM / physiology*