Abstract
We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed S. aureus. After 72 to 96 hours of treatment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P = .0031). Similar efficacy was demonstrated at 30 days. Mupirocin may be more effective than bacitracin for eradication of S. aureus in healthy HCWs.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / therapeutic use*
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Bacitracin / therapeutic use*
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Carrier State / drug therapy
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Cross Infection / prevention & control
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Female
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Humans
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Infection Control / methods*
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Infectious Disease Transmission, Professional-to-Patient / prevention & control
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Male
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Mupirocin / therapeutic use*
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Nasal Mucosa / microbiology
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Prospective Studies
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Single-Blind Method
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Staphylococcal Infections / prevention & control*
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Staphylococcus aureus / drug effects*
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Bacitracin
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Mupirocin