Prognostic factors in superficial adult soft tissue sarcomas: analysis of a series of 105 patients

J Surg Oncol. 1999 May;71(1):4-9. doi: 10.1002/(sici)1096-9098(199905)71:1<4::aid-jso2>3.0.co;2-w.

Abstract

Background and objectives: This study was undertaken to study the behavior of superficial soft tissue sarcomas (STS) and determine the factors related to prognosis.

Methods: The clinical records of 105 adults (56 men, 49 women, mean age: 56.4 years) were retrospectively analyzed. Univariate analysis was performed on the entire group for overall survival (OS), and metastasis-free survival (MFS). Local recurrence-free survival (LRFS) was studied only on patients first treated in our institute.

Results: With a median follow-up of 111.9 months, 66 (62.9%) patients were alive; 25 (23.8%) had died of their disease. For the entire series, 10-year OS and MFS were 62.5% and 71.9% respectively. For fifty-two patients treated for their sarcoma at the Institution since the first tumor occurrence event, 10-year LRFS was 80%. Tumor grade was the only factor correlated with OS and MFS, while tumor size was the main factor correlated with LRFS.

Conclusion: Tumor size affects local control in STS while tumor grade is correlated with OS and MFS.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Histiocytoma, Benign Fibrous / mortality
  • Humans
  • Leiomyosarcoma / mortality
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / mortality
  • Neoplasm Staging
  • Prognosis
  • Retrospective Studies
  • Sarcoma / mortality*
  • Sarcoma / pathology
  • Sarcoma / therapy
  • Soft Tissue Neoplasms / mortality*
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / therapy
  • Survival Rate