P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury

Brain Res. 1999 Jul 24;835(2):360-4. doi: 10.1016/s0006-8993(99)01637-6.

Abstract

We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cerebral Infarction / genetics
  • Cerebral Infarction / pathology
  • E-Selectin / genetics*
  • Genetic Engineering
  • Genetic Predisposition to Disease
  • Ischemic Attack, Transient / genetics*
  • Ischemic Attack, Transient / pathology
  • Mice
  • Mice, Transgenic
  • Necrosis
  • P-Selectin / genetics*
  • Reperfusion Injury / genetics*
  • Reperfusion Injury / pathology

Substances

  • E-Selectin
  • P-Selectin