Role of sugar re-puckering in the transition of A and B forms of DNA in solution. A molecular dynamics study

J Biomol Struct Dyn. 1999 Aug;17(1):89-99. doi: 10.1080/07391102.1999.10508343.

Abstract

State of the art molecular dynamic simulations show that simple modification of the sugar puckering of 2'deoxyriboses leads to a reversible change between two stable forms of DNA which resemble very closely the canonical A and B duplex forms. Analysis of the A-type and B-type structures reveals interesting, and previously unknown features of these two families of conformations of the DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbohydrates / chemistry*
  • Computer Simulation
  • DNA / chemistry*
  • Models, Molecular
  • Nucleic Acid Conformation*
  • Lösungen

Substances

  • Carbohydrates
  • Lösungen
  • DNA