Abstract
The effect of baseline drug resistance mutations on response to zidovudine, lamivudine, and ritonavir was evaluated in zidovudine-experienced persons infected with human immunodeficiency virus type 1 (HIV-1). Presence of the K70R mutation was associated with significantly higher plasma HIV-1 RNA levels at baseline. However, presence of resistance mutations did not affect the increase in plasma HIV-1 RNA during a 5-week drug washout, nor was there any effect on first-phase virus decay rates after initiation of therapy or on the probability of having plasma HIV-1 RNA levels <100 copies/mL at week 48. Polymorphisms at protease codons 10, 36, and 71 were associated with significantly faster second-phase decay rates. Suppression of plasma HIV-1 RNA despite presence of zidovudine resistance mutations implies that the presence of these mutations does not preclude a durable response to treatment with a potent 3-drug regimen.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Anti-HIV Agents / pharmacology
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Anti-HIV Agents / therapeutic use*
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Drug Resistance, Microbial / genetics
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Drug Therapy, Combination
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Female
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HIV Infections / drug therapy*
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HIV Infections / immunology
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HIV Infections / virology
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HIV Protease / genetics
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HIV Protease Inhibitors / therapeutic use
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HIV Reverse Transcriptase / genetics
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HIV-1 / drug effects*
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HIV-1 / genetics*
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Humans
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Lamivudine / therapeutic use
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Male
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Middle Aged
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Molecular Sequence Data
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Mutation
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RNA, Viral / blood
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Reverse Transcriptase Inhibitors / pharmacology*
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Reverse Transcriptase Inhibitors / therapeutic use
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Ritonavir / therapeutic use
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Viral Load
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Zidovudine / pharmacology*
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Zidovudine / therapeutic use
Substances
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Anti-HIV Agents
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HIV Protease Inhibitors
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RNA, Viral
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Reverse Transcriptase Inhibitors
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Lamivudine
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Zidovudine
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HIV Reverse Transcriptase
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HIV Protease
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Ritonavir
Associated data
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GENBANK/AF198391
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GENBANK/AF198392
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GENBANK/AF198393
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GENBANK/AF198394
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GENBANK/AF198395
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GENBANK/AF198396
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GENBANK/AF198397
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GENBANK/AF198398
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GENBANK/AF198399
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GENBANK/AF198400
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GENBANK/AF198401
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GENBANK/AF198402
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GENBANK/AF198403
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GENBANK/AF198404
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GENBANK/AF198405
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GENBANK/AF198406
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GENBANK/AF198407
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GENBANK/AF198408
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GENBANK/AF198409
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GENBANK/AF198410
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GENBANK/AF198411
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GENBANK/AF198412
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GENBANK/AF198413
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GENBANK/AF198414
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GENBANK/AF198415
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GENBANK/AF198416
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GENBANK/AF198417
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GENBANK/AF198418
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GENBANK/AF198419
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GENBANK/AF198420