A novel t(11;12)(q23-24;q24) in a case of minimally-differentiated acute myeloid leukemia (AML-M0)

Cancer Genet Cytogenet. 2000 Apr 1;118(1):76-9. doi: 10.1016/s0165-4608(99)00179-x.

Abstract

Acute myeloid leukemia with minimal signs of myeloid differentiation (AML-M0) is a recent addition to the FAB group classification. Chromosome data is scarce, but existing reports describe a high incidence of complex karyotypes and myelodysplastic syndrome-like chromosome alterations, while single chromosome translocations have rarely been reported. We describe the case of a 60-year-old woman diagnosed with AML-M0 with a novel translocation t(11;12)(q23-24;q24) as the sole karyotypic marker. Fluorescence in situ hybridization analysis to assess MLL gene splitting did not show rearrangement of this oncogene.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Cell Differentiation
  • Chromosome Banding
  • Chromosomes, Human, Pair 11 / genetics*
  • Chromosomes, Human, Pair 12 / genetics*
  • DNA-Binding Proteins / genetics
  • Fatal Outcome
  • Female
  • Histone-Lysine N-Methyltransferase
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Myeloid / drug therapy
  • Leukemia, Myeloid / genetics*
  • Leukemia, Myeloid / pathology*
  • Lymphocytes / metabolism
  • Middle Aged
  • Myelodysplastic Syndromes / genetics
  • Myeloid-Lymphoid Leukemia Protein
  • Proto-Oncogenes*
  • Recurrence
  • Transcription Factors*
  • Translocation, Genetic / genetics*

Substances

  • DNA-Binding Proteins
  • KMT2A protein, human
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase