Abstract
HP1 was first described in Drosophila as a heterochromatin-associated protein with dosage-dependent effects on heterochromatin-induced gene silencing. Recently, membership of the HP1 protein family has expanded tremendously. A number of intriguing interactions between HP1 and other proteins have been described, implicating HP1 in gene regulation, DNA replication, and nuclear architecture.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Chromatin / genetics*
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Chromatin / metabolism*
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Chromobox Protein Homolog 5
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Chromosomal Proteins, Non-Histone / genetics*
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Chromosomal Proteins, Non-Histone / metabolism*
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Humans
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Multigene Family
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Protein Binding / genetics
Substances
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Chromatin
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Chromosomal Proteins, Non-Histone
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Chromobox Protein Homolog 5