Abstract
The E7 oncoprotein encoded by human papillomavirus (HPV) type 16 repressed the transcription of fibronectin, a key component of the extracellular matrix. This repression, detected in several HPV-positive nontumorigenic and tumorigenic cell lines, was abolished when the Cys-X-X-Cys repeats in E7 were disrupted.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cell Line
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Down-Regulation
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Female
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Fibronectins / genetics*
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Fibronectins / metabolism
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Humans
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Luciferases / metabolism
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Oncogene Proteins, Viral / genetics
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Oncogene Proteins, Viral / metabolism*
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Papillomaviridae / genetics
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Papillomaviridae / metabolism*
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Papillomavirus E7 Proteins
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Papillomavirus Infections / virology
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Repressor Proteins / genetics
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Repressor Proteins / metabolism*
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Transcription, Genetic*
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Tumor Cells, Cultured
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Tumor Virus Infections / virology
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Uterine Cervical Neoplasms / virology
Substances
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Fibronectins
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Oncogene Proteins, Viral
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Papillomavirus E7 Proteins
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Repressor Proteins
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oncogene protein E7, Human papillomavirus type 16
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Luciferases