Abstract
Peptide nucleic acid (PNA) conjugated peptides, derived from HIV-1 Rev, were designed and synthesized in order to construct molecules that recognize HIV RRE IIB RNA. The competitive binding analyses using fluorescent Rev peptide revealed that the PNA unit on the peptide affected the RNA binding.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Drug Design
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Gene Products, rev / chemistry*
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HIV-1*
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Indicators and Reagents
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Molecular Sequence Data
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Nucleic Acid Conformation
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Peptide Nucleic Acids / chemical synthesis
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Peptide Nucleic Acids / chemistry*
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RNA, Viral / chemistry*
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rev Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, rev
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Indicators and Reagents
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Peptide Nucleic Acids
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RNA, Viral
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rev Gene Products, Human Immunodeficiency Virus