Presenilin-1 mutations in Alzheimer's disease

Nature. 2000 Jun 1;405(6786):531-2. doi: 10.1038/35014735.
No abstract available

MeSH terms

  • Age of Onset
  • Alzheimer Disease / genetics*
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Protein Precursor / chemistry
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / metabolism
  • Aspartic Acid Endopeptidases
  • Brain / metabolism
  • Endopeptidases / metabolism
  • Humans
  • Membrane Proteins / genetics*
  • Mutation*
  • Presenilin-1

Substances

  • Amyloid beta-Protein Precursor
  • Membrane Proteins
  • PSEN1 protein, human
  • Presenilin-1
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human