Abstract
A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cinnamates / chemical synthesis*
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Cinnamates / chemistry
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Cinnamates / pharmacology
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Cyclin D1 / antagonists & inhibitors*
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinases / antagonists & inhibitors*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Kinetics
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Molecular Structure
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Proto-Oncogene Proteins*
Substances
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Cinnamates
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Enzyme Inhibitors
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Proto-Oncogene Proteins
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p-hydroxycinnamaldehyde
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Cyclin D1
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinases