Abstract
The integral membrane protein complex quinol-fumarate reductase catalyzes the terminal step of a major anaerobic respiratory pathway. The homologous enzyme succinate-quinone oxidoreductase participates in aerobic respiration both as complex II and as a member of the Krebs cycle. Last year, two structures of quinol-fumarate reductases were reported. These structures revealed the cofactor organization linking the fumarate and quinol sites, and showed a cofactor arrangement across the membrane that is suggestive of a possible energy coupling function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Electron Transport
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Electron Transport Complex II
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Energy Metabolism
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Intracellular Membranes / metabolism
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Multienzyme Complexes / chemistry*
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Multienzyme Complexes / metabolism
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Oxidoreductases / chemistry*
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Oxidoreductases / metabolism
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Protein Conformation
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Quinones / chemistry*
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Quinones / metabolism
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Succinate Dehydrogenase / chemistry*
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Succinate Dehydrogenase / metabolism
Substances
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Multienzyme Complexes
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Quinones
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Oxidoreductases
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Electron Transport Complex II
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Succinate Dehydrogenase