Abstract
Culture supernatants prepared from reactogenic strains of Vibrio cholerae cause a decrease in the transcellular epithelial resistance of T84 intestinal cells. This decrease correlates with the presence of hemagglutinin/protease but not with the presence of other potential accessory toxins or proteases. These data suggest a possible role for hemagglutinin/protease in reactogenicity, although other factors may also contribute.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aminopeptidases / physiology
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Cell Line
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Cell Polarity
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Cholera Toxin / biosynthesis
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Cholera Vaccines*
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Endopeptidases / physiology*
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Endotoxins
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Hemagglutinins / physiology
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Intestinal Mucosa / physiology*
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Vibrio cholerae / physiology*
Substances
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Cholera Vaccines
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Endotoxins
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Hemagglutinins
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zonula occludens toxin, Vibrio cholerae
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Cholera Toxin
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Endopeptidases
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Aminopeptidases