Abstract
The clonality of peripheral blood cells was assessed in eight female patients with myelodysplastic syndrome (MDS) by means of the human androgen receptor gene-based assay (HUMARA). The patients were in complete remission for a median follow-up time of 83 months after intensive chemotherapy. X-chromosome inactivation patterns (XCIPs) indicated polyclonal haemopoiesis in five patients. Two patients had skewed lyonization (i.e. unbalanced XCIPs in both granulocytes and T cells) and one patient presented monoclonal granulocytes together with polyclonal T cells. We conclude that long-term remission in MDS following intensive chemotherapy is usually associated with polyclonal haemopoiesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cyclophosphamide / administration & dosage
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Cytarabine / administration & dosage
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Daunorubicin / administration & dosage
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Dosage Compensation, Genetic
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Female
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Follow-Up Studies
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Hematopoiesis*
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Humans
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Idarubicin / administration & dosage
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Middle Aged
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Mitoxantrone / administration & dosage
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Myelodysplastic Syndromes / blood*
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Myelodysplastic Syndromes / drug therapy*
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Myelodysplastic Syndromes / genetics
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Retrospective Studies
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Thioguanine / administration & dosage
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Time Factors
Substances
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Cytarabine
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Cyclophosphamide
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Mitoxantrone
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Thioguanine
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Idarubicin
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Daunorubicin