Abstract
Central administration of amylin (2.2 microg/rat, i.c.v.) reduces (from a minimum of 67% to 83%) indomethacin (Indo, 20 mg Kg(-1), orally) induced ulcers in rats. The anti-ulcer effect of the peptide is not removed by the administration of prokinetic drugs like domperidone or neostigmine but it is reduced by 35% in rats treated with capsaicin or with the CGRP antagonist, CGRP(8-37). These data indicate that amylin gastroprotection involves capsaicin-sensitive nerve fiber leading to CGRP-dependent gastric vasodilatory effect. Additional mechanisms could involve noradrenergic alpha(2) receptors as the peptide gastroprotective activity is reduced from 67% to 20% by the alpha(2) antagonist yohimbine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Antagonists / pharmacology
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Amyloid / administration & dosage
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Amyloid / pharmacology*
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Animals
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Anti-Ulcer Agents / administration & dosage
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Anti-Ulcer Agents / pharmacology*
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Calcitonin Gene-Related Peptide / antagonists & inhibitors
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Calcitonin Gene-Related Peptide / metabolism
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Calcitonin Gene-Related Peptide / pharmacology
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Capsaicin / pharmacology
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Domperidone / pharmacology
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Indomethacin / pharmacology
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Islet Amyloid Polypeptide
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Male
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Neostigmine / pharmacology
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Neurons, Afferent / drug effects
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Neurons, Afferent / physiology*
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Peptide Fragments / pharmacology
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Rats
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Rats, Sprague-Dawley
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Stomach Ulcer / chemically induced*
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Yohimbine / pharmacology
Substances
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Adrenergic alpha-Antagonists
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Amyloid
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Anti-Ulcer Agents
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Islet Amyloid Polypeptide
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Peptide Fragments
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calcitonin gene-related peptide (8-37)
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Yohimbine
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Neostigmine
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Domperidone
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Calcitonin Gene-Related Peptide
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Capsaicin
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Indomethacin