Isolation and structure elucidation of a novel griseorhodin

J Antibiot (Tokyo). 1979 Mar;32(3):197-204. doi: 10.7164/antibiotics.32.197.

Abstract

Three antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A. A second, FCRC-57-U, was found to be identical to griseorhodin C. FCRC-57-G is a new antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new antibiotic was determined using mass spectrometry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / analysis*
  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / isolation & purification
  • Chemical Phenomena
  • Chemistry
  • Chemistry, Physical
  • Fermentation
  • Naphthoquinones / analysis
  • Naphthoquinones / biosynthesis
  • Naphthoquinones / isolation & purification
  • Streptomyces griseus / metabolism

Substances

  • Anti-Bacterial Agents
  • Naphthoquinones