Abstract
[reaction: see text] A pyrrolinone-based hydroxamate matrix metalloprotease inhibitor, (-)-1, has been designed and synthesized. Enzymatic assay revealed that (-)-1 inhibited three of the ten matrix metalloprotease enzymes examined and as such represents a new, potentially important lead structure.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aldehydes
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Drug Design
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Isoenzymes / antagonists & inhibitors
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Metalloendopeptidases / antagonists & inhibitors*
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Metalloendopeptidases / chemistry
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Models, Molecular
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / chemistry
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry
Substances
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Aldehydes
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Isoenzymes
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Protease Inhibitors
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Pyrroles
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Metalloendopeptidases