Diagnostic and prognostic role of myoglobin in patients with suspected acute coronary syndrome. North-Württemberg Infarction Study (NOWIS) Group

Am J Cardiol. 2000 Dec 15;86(12):1371-4, A5. doi: 10.1016/s0002-9149(00)01246-7.

Abstract

In patients with suspected acute coronary syndrome, myoglobin is, according to IFCC and NACB guidelines, the marker of choice for early determination of acute infarction, in particular in combination with creatine kinase-MB, 4 hours after admission with a sensitivity of 96%, and correctly excludes Q-wave infarctions. In patients without acute myocardial infarction, a positive troponin T (relative risk 31.5%), but not an elevated myoglobin (relative risk 4.5%), is highly predictive for adverse in-hospital outcome.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Angina, Unstable / blood
  • Angina, Unstable / diagnosis*
  • Confidence Intervals
  • Coronary Disease / blood
  • Coronary Disease / diagnosis
  • Creatine Kinase / blood
  • Creatine Kinase, MB Form
  • Electrocardiography
  • Female
  • Forecasting
  • Humans
  • Isoenzymes / blood
  • Male
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / diagnosis*
  • Myoglobin / blood*
  • Odds Ratio
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Troponin T / blood

Substances

  • Isoenzymes
  • Myoglobin
  • Troponin T
  • Creatine Kinase
  • Creatine Kinase, MB Form