Abstract
The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a longstanding puzzle in immunology. In the past few years it has become clear that production of mu heavy chain and subsequent assembly with surrogate light chain to form the pre-B cell receptor complex is critical to promote development of adult B cell precursors in mouse bone marrow. Recently we found that instead of promoting pre-B cell expansion as in adult bone marrow, this complex inhibits pre-B cell growth in fetal liver, providing a previously unrecognized mechanism for alteration of the B cell repertoire with age. The consequence is very distinct primary repertoires for development of fetal B1 cells and adult bone marrow B2 cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adult
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Animals
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Antibody Specificity / immunology*
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B-Lymphocyte Subsets / cytology*
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B-Lymphocyte Subsets / immunology
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Bone Marrow / immunology*
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Cell Lineage
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Gene Rearrangement, B-Lymphocyte*
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Gene Rearrangement, B-Lymphocyte, Heavy Chain
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Genes, Immunoglobulin
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Hematopoiesis, Extramedullary / immunology*
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / immunology
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Humans
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Immune System / embryology
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Immune System / growth & development*
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Immunoglobulin Variable Region / genetics
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Immunoglobulin mu-Chains / genetics
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Liver / cytology
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Liver / embryology*
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Liver / immunology
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Mice
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Mice, Transgenic
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Receptors, Antigen, B-Cell / genetics
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Receptors, Antigen, B-Cell / immunology*
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Recombinant Fusion Proteins / immunology
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Transfection
Substances
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Immunoglobulin Variable Region
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Immunoglobulin mu-Chains
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Receptors, Antigen, B-Cell
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Recombinant Fusion Proteins