Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells

Ann N Y Acad Sci. 2000:920:259-60. doi: 10.1111/j.1749-6632.2000.tb06933.x.

Authors

L A Ingano¹, K M Lentini, I Kovacs, R E Tanzi, D M Kovacs

Affiliation

¹ Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

PMID: 11193161
DOI: 10.1111/j.1749-6632.2000.tb06933.x

No abstract available

MeSH terms

Adenosine Triphosphatases / metabolism
Alzheimer Disease / pathology
Animals
Brain / pathology
Cysteine Endopeptidases / metabolism*
Humans
Membrane Proteins / drug effects
Membrane Proteins / metabolism*
Membrane Proteins / ultrastructure
Multienzyme Complexes / metabolism*
Neurofibrillary Tangles / pathology
Presenilin-1
Protease Inhibitors / pharmacology*
Proteasome Endopeptidase Complex
Recombinant Proteins / metabolism
Recombinant Proteins / ultrastructure
Transfection

Substances

Membrane Proteins
Multienzyme Complexes
PSEN1 protein, human
Presenilin-1
Protease Inhibitors
Recombinant Proteins
Cysteine Endopeptidases
Proteasome Endopeptidase Complex
Adenosine Triphosphatases