Abstract
Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Cell Line
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Cell Membrane / metabolism
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Enfuvirtide
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Genetic Vectors
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HIV Envelope Protein gp41 / chemistry
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HIV Envelope Protein gp41 / genetics
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HIV Envelope Protein gp41 / metabolism
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HIV Envelope Protein gp41 / physiology*
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HIV-1 / physiology*
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Humans
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Molecular Sequence Data
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Peptide Fragments / chemistry
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Peptide Fragments / genetics
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Peptide Fragments / metabolism
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Peptide Fragments / physiology*
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Retroviridae / genetics
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T-Lymphocytes, Helper-Inducer / virology*
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Transduction, Genetic
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Virus Replication
Substances
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HIV Envelope Protein gp41
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Peptide Fragments
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Enfuvirtide