Radiation-induced granulocyte transmigration predicts development of delayed structural changes in rat intestine

K K Richter; J Wang; M K Fagerhol; M Hauer-Jensen

doi:10.1016/s0167-8140(00)00302-9

Radiation-induced granulocyte transmigration predicts development of delayed structural changes in rat intestine

Radiother Oncol. 2001 Apr;59(1):81-5. doi: 10.1016/s0167-8140(00)00302-9.

Authors

K K Richter¹, J Wang, M K Fagerhol, M Hauer-Jensen

Affiliation

¹ Department of Surgery, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.

PMID: 11295210
DOI: 10.1016/s0167-8140(00)00302-9

Abstract

We examined whether early radiation-induced granulocyte transmigration (assessed by the fecal transferrin excretion ELISA assay) predicts subsequent development of (consequential) chronic radiation enteropathy. After accounting for the effect of radiation dose, transferrin excretion remained an independent predictor of overall tissue injury, intestinal fibrosis, and mucosal ulcers, but not TGF-beta immunoreactivity.

Publication types

Comparative Study

MeSH terms

Animals
Cell Movement / radiation effects*
Culture Techniques
Disease Models, Animal
Dose-Response Relationship, Radiation
Enzyme-Linked Immunosorbent Assay
Feces / chemistry*
Granulocytes / radiation effects
Injury Severity Score
Intestine, Small / radiation effects*
Multivariate Analysis
Predictive Value of Tests
Probability
ROC Curve
Radiation Dosage
Radiation Injuries, Experimental / pathology*
Rats
Reference Values
Transferrin / analysis*
Transforming Growth Factor beta / analysis*

Substances

Transferrin
Transforming Growth Factor beta