Abstract
This study demonstrates for the first time that vaccination with either autologous or heterologous dendritic cells (DC) pulsed with specific antigen induces protective immune responses against noninvasive bacteria, namely Bordetella pertussis. The DC-mediated protection is associated with strong B. pertussis-specific immunoglobulin G (IgG) and IgA responses in the lung.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Bacterial / blood
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Antibodies, Bacterial / immunology
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Antigen-Presenting Cells / immunology*
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Antigens, Bacterial / immunology
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Bacterial Vaccines / immunology
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Bordetella pertussis / immunology*
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Dendritic Cells / cytology
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Dendritic Cells / immunology*
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Immunity, Mucosal
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Lung / microbiology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Transplantation, Autologous / immunology
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Transplantation, Heterologous / immunology
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Vaccination*
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Whooping Cough / microbiology
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Whooping Cough / prevention & control*
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Vaccines