Effects of carboxyl-terminal fragment of Alzheimer's amyloid precursor protein and amyloid beta-peptide on the production of cytokines and nitric oxide in glial cells

FASEB J. 2001 Jun;15(8):1463-5. doi: 10.1096/fj.00-0724fje.

Authors

J C Rah¹, H S Kim, S S Kim, J H Bach, Y S Kim, C H Park, J H Seo, S J Jeong, Y H Suh

Affiliation

¹ Department of Pharmacology, College of Medicine, National Creative Research Initiative Centre for Alzheimer's Dementia and Neuroscience Research Institute, Medical Research Centre, Seoul National University, Seoul 110-799, Republic of Korea.

PMID: 11387258
DOI: 10.1096/fj.00-0724fje

No abstract available

MeSH terms

Amyloid beta-Peptides / pharmacology*
Amyloid beta-Protein Precursor / pharmacology*
Animals
Astrocytes / cytology
Astrocytes / drug effects
Cell Death
Cells, Cultured
Cerebral Cortex / cytology
Chemokine CCL2 / biosynthesis
Chemokine CCL4
Chemokine CCL5 / biosynthesis
Condiments
Cytokines / biosynthesis*
Interleukin-1 / biosynthesis
Macrophage Inflammatory Proteins / biosynthesis
Microglia / drug effects
Models, Biological
Neuroglia / cytology
Neuroglia / drug effects*
Neurons / cytology
Nitric Oxide / biosynthesis*
Peptide Fragments / pharmacology*
Rats
Tumor Necrosis Factor-alpha / biosynthesis

Substances

Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Chemokine CCL2
Chemokine CCL4
Chemokine CCL5
Cytokines
Interleukin-1
Macrophage Inflammatory Proteins
Peptide Fragments
Tumor Necrosis Factor-alpha
amyloid beta-protein (1-42)
amyloid beta-protein precursor CT105
Nitric Oxide