Revised interpretation of the immunological results obtained with pneumococcal polysaccharide 17F derived synthetic di-, tri- and tetrasaccharide conjugates in mice and rabbits

W T Jansen; A F Verheul; G H Veeneman; J H van Boom; H Snippe

doi:10.1016/s0264-410x(01)00263-8

Revised interpretation of the immunological results obtained with pneumococcal polysaccharide 17F derived synthetic di-, tri- and tetrasaccharide conjugates in mice and rabbits

Vaccine. 2001 Oct 12;20(1-2):19-21. doi: 10.1016/s0264-410x(01)00263-8.

Authors

W T Jansen¹, A F Verheul, G H Veeneman, J H van Boom, H Snippe

Affiliation

¹ Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, Vaccines Section, Utrecht University Hospital, 3584 CX, Utrecht, The Netherlands. [email protected]

PMID: 11567741
DOI: 10.1016/s0264-410x(01)00263-8

Abstract

Recently, the structure for pneumococcal polysaccharide (PS) 17F has been revised. Based on the former PS structure, immunogenicities of PS 17F derived synthetic di-, tri- and tetrasaccharide conjugates have been reported in mice. Here, we present additional data on the immunogenicities of these conjugates in rabbits and re-evaluate the immunogenicity results in the light of the revised PS 17F structure.

MeSH terms

Animals
Antibodies, Bacterial / biosynthesis
Antigens, Bacterial / chemistry
Antigens, Bacterial / immunology
Carbohydrate Sequence
Immunization Schedule
Mice
Molecular Sequence Data
Molecular Structure
Pneumococcal Vaccines / immunology*
Polysaccharides, Bacterial / chemistry
Polysaccharides, Bacterial / immunology*
Rabbits
Streptococcus pneumoniae / immunology
Vaccination
Vaccines, Conjugate / immunology
Vaccines, Synthetic / immunology

Substances

Antibodies, Bacterial
Antigens, Bacterial
Pneumococcal Vaccines
Polysaccharides, Bacterial
Vaccines, Conjugate
Vaccines, Synthetic
pneumococcal polysaccharide type 17F