Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders

Mech Ageing Dev. 2001 Nov;122(16):2005-11. doi: 10.1016/s0047-6374(01)00304-9.

Abstract

The reliability of cerebrospinal fluid (CSF)-tau and CSF-beta-amyloid assays for diagnosis of Alzheimer's disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSF-tau levels can discriminate CJD from AD.

Publication types

  • Review

MeSH terms

  • Amyloid beta-Peptides / cerebrospinal fluid*
  • Dementia / cerebrospinal fluid*
  • Dementia / diagnosis
  • Humans
  • Peptide Fragments / cerebrospinal fluid*
  • Time Factors
  • tau Proteins / cerebrospinal fluid*

Substances

  • Amyloid beta-Peptides
  • Peptide Fragments
  • amyloid beta-protein (1-42)
  • tau Proteins