Cytostatic activity of Achillea ageratum L

Phytother Res. 2001 Nov;15(7):633-4. doi: 10.1002/ptr.837.

Abstract

The cytostatic activity of a chloroform extract and two isolated compounds from Achillea ageratum L. (Asteraceae) was determined in vitro against Hep-2 and McCoy cells. The chloroform extract exhibited a high degree of growth inhibition compared with the values obtained with the 6-mercaptopurine (positive control) against both cultures. Stigmasterol and beta-sitosterol, isolated from the chloroform extract, showed a high degree of growth inhibition.

MeSH terms

  • Antineoplastic Agents / toxicity*
  • Asteraceae*
  • Humans
  • Inhibitory Concentration 50
  • Phytotherapy*
  • Plant Extracts / toxicity*
  • Sitosterols / toxicity*
  • Stigmasterol / toxicity*
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • Plant Extracts
  • Sitosterols
  • gamma-sitosterol
  • Stigmasterol