Inverse regulation of interleukin-6 (IL-6) and IL-6 receptor in histamine deficient histidine decarboxylase-knock-out mice

B V Horváth; A Falus; S Tóth; Cs Szalai; E Lázár-Molnár; M Cs Holub; E Buzás; A Nagy; A K Fulop

doi:10.1016/s0165-2478(01)00329-7

Inverse regulation of interleukin-6 (IL-6) and IL-6 receptor in histamine deficient histidine decarboxylase-knock-out mice

Immunol Lett. 2002 Mar 1;80(3):151-4. doi: 10.1016/s0165-2478(01)00329-7.

Authors

B V Horváth¹, A Falus, S Tóth, Cs Szalai, E Lázár-Molnár, M Cs Holub, E Buzás, A Nagy, A K Fulop

Affiliation

¹ Department of Genetics, Cell and Immunobiology, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary.

PMID: 11803046
DOI: 10.1016/s0165-2478(01)00329-7

Abstract

Interleukin-6, a multifunctional cytokine upon binding to its receptor on hepatocytes regulates production of acute phase proteins involved in local and systemic inflammation. Gene expression and biosynthesis of IL-6 and its receptor (IL-6 R/gp130) is under complex regulation. Histamine, in addition to its principal role in immediate type hypersensitivity has been described to modulate IL-6 production and expression of IL-6 receptor. In this study, the IL-6 and IL-6 receptor expression was examined in histamine deficient histidine decarboxylase (HDC) knock-out mouse model. Our data suggest that in histamine deficient mice the inducibility of IL-6 is significantly reduced, whilst more IL-6 receptor/gp130 mRNA expresses in the liver than in wild type (HDC(+/+)) mice. These in vivo findings confirm earlier in vitro results and emphasize the efficacy of antihistamines in local IL-6 related processes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, CD / genetics
Antigens, CD / metabolism
Cytokine Receptor gp130
Gene Deletion
Gene Expression Regulation*
Gene Frequency
Histamine / genetics
Histamine / metabolism*
Histidine Decarboxylase / deficiency*
Histidine Decarboxylase / genetics
Histidine Decarboxylase / metabolism
Interleukin-6 / blood
Interleukin-6 / metabolism*
Leukemia Inhibitory Factor Receptor alpha Subunit
Liver / metabolism
Membrane Glycoproteins / genetics
Membrane Glycoproteins / metabolism
Mice
Mice, Knockout
RNA, Messenger / genetics
RNA, Messenger / metabolism
Receptors, Cytokine / genetics
Receptors, Cytokine / metabolism
Receptors, Interleukin-6 / genetics
Receptors, Interleukin-6 / metabolism*
Receptors, OSM-LIF

Substances

Antigens, CD
Il6st protein, mouse
Interleukin-6
Leukemia Inhibitory Factor Receptor alpha Subunit
Lifr protein, mouse
Membrane Glycoproteins
RNA, Messenger
Receptors, Cytokine
Receptors, Interleukin-6
Receptors, OSM-LIF
Cytokine Receptor gp130
Histamine
Histidine Decarboxylase