Abstract
The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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AIDS Vaccines / administration & dosage
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AIDS Vaccines / immunology*
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Animals
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HIV Infections / prevention & control
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HIV-1 / immunology
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Humans
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Macaca
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Simian Acquired Immunodeficiency Syndrome / prevention & control*
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Simian Acquired Immunodeficiency Syndrome / virology*
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Simian Immunodeficiency Virus / immunology
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Simian Immunodeficiency Virus / physiology*
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T-Lymphocytes, Cytotoxic / immunology
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Vaccination
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Vaccines, DNA / administration & dosage
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Vaccines, DNA / immunology
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Vaccinia virus / genetics
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Viral Load
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Virus Replication*
Substances
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AIDS Vaccines
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Vaccines, DNA
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human immunodeficiency virus type 1 Tat vaccine