Abstract
Delayed hypersensitivity to heparins and heparinoïd is a problem for prophylaxis of thrombo embolic diseases. The hirudins did not seem to have any cross-reactivity with the two others groups of anticoagulants. We present two clinical cases of delayed type reactions to heparins and heparinoïd and we reviewed the literature about adverse reactions to low molecular weight heparins and the alternative possibilities.
MeSH terms
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Aged
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Anticoagulants / adverse effects
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Anticoagulants / immunology
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Chondroitin Sulfates / adverse effects
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Chondroitin Sulfates / immunology
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Cross Reactions
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Dalteparin / adverse effects
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Dalteparin / immunology
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Dermatan Sulfate / adverse effects
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Dermatan Sulfate / immunology
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Drug Combinations
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Drug Hypersensitivity / etiology*
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Enoxaparin / adverse effects
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Enoxaparin / immunology
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Female
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Heparin / adverse effects*
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Heparin / immunology
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Heparin, Low-Molecular-Weight / adverse effects*
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Heparin, Low-Molecular-Weight / immunology
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Heparitin Sulfate / adverse effects
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Heparitin Sulfate / immunology
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Hirudin Therapy
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Hirudins / analogs & derivatives*
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Humans
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Hypersensitivity, Delayed / chemically induced*
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Nadroparin / adverse effects
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Nadroparin / immunology
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Recombinant Proteins / therapeutic use
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Skin Tests
Substances
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Anticoagulants
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Drug Combinations
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Enoxaparin
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Heparin, Low-Molecular-Weight
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Hirudins
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Nadroparin
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Recombinant Proteins
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Dermatan Sulfate
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Heparin
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Chondroitin Sulfates
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Heparitin Sulfate
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danaparoid
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Dalteparin
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desirudin