Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei

Mol Biochem Parasitol. 2002 Jul;122(2):217-21. doi: 10.1016/s0166-6851(02)00096-8.

Authors

Arun Pal¹, Belinda S Hall, Mark C Field

Affiliation

¹ Wellcome Trust Laboratories for Molecular Parasitology, Department of Biological Sciences and Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology and Medicine, Exhibition Road, SW7 2AY, London, UK.

PMID: 12106876
DOI: 10.1016/s0166-6851(02)00096-8

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Endocytosis*
Lipoproteins, LDL / metabolism*
Parasitic Sensitivity Tests / methods
Receptors, LDL / metabolism
Suramin / metabolism*
Suramin / pharmacology
Trypanocidal Agents / metabolism*
Trypanocidal Agents / pharmacology
Trypanosoma brucei brucei / drug effects
Trypanosoma brucei brucei / genetics
Trypanosoma brucei brucei / metabolism*
Trypanosomiasis, African / parasitology
rab4 GTP-Binding Proteins / genetics
rab4 GTP-Binding Proteins / metabolism
rab5 GTP-Binding Proteins / genetics
rab5 GTP-Binding Proteins / metabolism

Substances

Lipoproteins, LDL
Receptors, LDL
Trypanocidal Agents
Suramin
rab4 GTP-Binding Proteins
rab5 GTP-Binding Proteins