Abstract
By using mice genomically lacking the mononuclear phagocytic growth factor colony-stimulating factor 1 and thereby deficient in macrophage and dendritic cell populations, we show that these cells play a dual role: they constitute a major defense against systemic infection but also facilitate cerebral bacterial invasion by Listeria monocytogenes.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antigens, Differentiation / immunology
-
B7-1 Antigen / immunology
-
Brain Stem / microbiology
-
Dendritic Cells / immunology*
-
Integrin alphaXbeta2 / immunology
-
Listeria monocytogenes / immunology
-
Listeria monocytogenes / pathogenicity
-
Listeriosis / immunology*
-
Listeriosis / microbiology
-
Liver / microbiology
-
Macrophage Colony-Stimulating Factor / genetics
-
Macrophage Colony-Stimulating Factor / immunology*
-
Macrophages / immunology*
-
Mice
-
Mice, Knockout
-
Neurons / immunology
-
Neurons / microbiology*
-
Phospholipases / genetics
-
Phospholipases / immunology
-
Spleen / microbiology
-
Trigeminal Ganglion / microbiology
Substances
-
Antigens, Differentiation
-
B7-1 Antigen
-
Integrin alphaXbeta2
-
monocyte-macrophage differentiation antigen
-
Macrophage Colony-Stimulating Factor
-
Phospholipases